Dr Ray O’Connor takes a have a look at the most recent scientific articles with reference to headache, together with its preliminary prognosis and managment
Complications are one of the crucial frequent problems of the nervous system and one of many largest contributors to incapacity. Main headache problems are recurrent complications that aren’t attributable to one other underlying medical situation. Frequent examples embody migraines, tension-type complications, and cluster complications. Secondary complications are often attributable to an underlying situation e.g. meningitis or cranial arteritis.
This useful scientific evaluation1 appears on the preliminary prognosis and administration of acute headache. The authors focus on how a clinician’s purpose when encountering acute complications is to tell apart major and secondary headache problems.

Dr Ray O’Connor
They advocate a complete historical past, screening for warning indicators of secondary headache, and a bodily examination. These can assist decide if additional workup is important. Whereas neurodiagnostic testing is often not indicated for people with a historical past of major headache problems with typical signs, people with atypical indicators or signs could warrant mind imaging with MRI mind, CT head, or referral for specialist analysis that will embody additional checks corresponding to CT angiogram, standard cerebral angiography, backbone imaging, and/or lumbar puncture.
Secondary complications must be handled for his or her underlying trigger. Main headache problems have particular evidence-based remedies that may assist with acute ache reduction.
One other helpful evaluation2 which relies in Emergency Departments factors out that whereas most complications are major in nature, it’s important to display for headache “pink flags” as they will counsel life threatening secondary aetiologies.
The completely different scientific displays for secondary complications, in addition to the distinguishing options for major complications are outlined within the evaluation. They counsel a really helpful mnemonic ‘SNNOOP10’ that considers the “pink flag” options that will counsel an underlying secondary aetiology for acute or subacute complications.
The mnemonic stands for: systemic signs together with fever, neoplasm historical past, neurological focal deficits, onset sudden, older age group (>50 years), sample of headache change, positional headache in nature, precipitating components, being pregnant or puerperium, painful eye with autonomic options, publish traumatic onset of headache, pathology of the immune system e.g. HIV constructive, painkiller overuse headache, or onset with a brand new treatment.
Identification of gear that will trigger or set off headache is the topic of one other evaluation.3 The authors level out that you will need to begin efficient remedy early to forestall pointless struggling, deterioration in high quality of life, and the event of power ache. They argue that remedy in case of treatment overuse and different power headache must be decisive and efficient. Drug withdrawal and introduction of efficient prophylactic treatment for the underlying headache dysfunction must be the first remedy technique.
They record typical headache-inducing substances together with nitric oxide, phosphodiesterase, cocaine, alcohol, histamine and carbon oxide. In addition they level out that withdrawal of caffeine, oestrogen, and opioids is most frequently related to the event of headache.
Traumatic mind harm (TBI) is estimated to rank because the third most essential illness burden worldwide. The authors of this evaluation of the subject4 describe how roughly 60 per cent of the survivors of TBI develop power complications and visible signs, and the long-term administration of complications in these sufferers is controversial.
They describe how the care pathway of most sufferers is fragmented, complicating conclusive headache administration. In addition they evaluation the epidemiology and aetiology of publish traumatic complications, focus on the diagnostic work up and summarise it’s acute and long-term administration.
Regardless of the truth that it’s a frequent concern in individuals presenting with headache, the authors of this evaluation on the subject5 level out that the prevalence of mind tumours in sufferers with headache could be very low. In addition they describe that between 48 per cent and 71 per cent of sufferers with mind tumours expertise headache.
Medical presentation of headache in mind tumours varies in accordance with various factors together with age; intracranial stress; tumour location, kind, and development; headache historical past; and remedy. Mind tumour-associated complications might be attributable to native and distant traction on pain-sensitive cranial constructions, mass impact attributable to the enlarging tumour and cerebral oedema, infarction, haemorrhage, hydrocephalus, and tumour secretion. This text then focuses on headache in affiliation with mind tumours.
References:
- Parikh S. Acute Headache Prognosis and Administration. Med Clin North Am. 2025 Mar;109(2):529-541. doi: 10.1016/j.mcna.2024.10.004. Epub 2024 Dec 10.
- Hernandez J et al. Overview: Headache Issues: Differentiating Main and Secondary Etiologies. J. Integr. Neurosci. 2024; 23(2): 43 https://doi.org/10.31083/j.jin2302043
- Obermann M et al. Headache Attributed to a Substance or Its Withdrawal. Neurol Clin. 2024 Might;42(2):497-506. doi: 10.1016/j.ncl.2023.12.005.
- Teli P et al. Headache administration in traumatic mind harm. J Neurol Sci 2024 Aug 15:463:123002. doi: 10.1016/j.jns.2024.123002.
- Cho S et al. Headache in Mind Tumors. Neurol Clin 2024 Might;42(2):487-496. doi:10.1016/j.ncl.2023.12.004.