In February 2024, the U.S. Division of Well being and Human Companies Panel for the Use of Antiretroviral Brokers in Adults and Adolescents with HIV (ARV Pointers Panel), in collaboration with the American Faculty of Cardiology (ACC), the American Coronary heart Affiliation (AHA), and the HIV Drugs Affiliation (HIVMA), developed statin remedy suggestions for folks with HIV (PWH).
These suggestions have been knowledgeable by the outcomes of the REPRIEVE (Randomized Trial to Stop Vascular Occasions in HIV) research. A abstract of the suggestions related to physicians is printed in Annals of Inner Drugs.
PWH are extra in danger for a lot of aging-related illnesses, together with atherosclerotic heart problems (ASCVD). The REPRIEVE research was a Part III, international, randomized managed trial of oral pitavastatin versus placebo for the prevention of ASCVD in PWH aged 40 to 75 years at low to intermediate danger primarily based on 10-year danger estimates.
In contrast with placebo, pitavastatin was related to a 36% discount in MACE. These findings knowledgeable the ARV panel to advocate moderate-intensity statin remedy as the first prevention amongst PWH aged 40 to 75 years with low to intermediate 10-year ASCVD danger.
The panel additionally strongly recommends initiating statin remedy amongst folks with a 10-year ASCVD danger rating of 5% or larger.
For PWH with a 10-year ASCVD danger rating under 5%, the panel favored statin remedy but in addition advisable that affected person–clinician danger discussions think about HIV-related components than can improve ASCVD danger.
Amongst PWH youthful than 40 years, choices to provoke statin remedy must be individualized and primarily based on danger components and familial well being historical past. The panel recommends the usage of not less than moderate-intensity statins, together with pitavastatin, 4 mg day by day; atorvastatin, 20 mg day by day; or rosuvastatin, 10 mg day by day.
The authors be aware that future analysis is required to raised perceive absolutely the danger for ASCVD and different nonischemic CVD manifestations in folks with HIV.
Extra info:
Statin Remedy as Main Prevention for Individuals with HIV: Suggestions from the U.S. HHS Antiretroviral Remedy Pointers Panel, Annals of Inner Drugs (2025). DOI: 10.7326/ANNALS-24-03564
Quotation:
Panel recommends statins for adults with HIV in danger for heart problems (2025, Could 26)
retrieved 26 Could 2025
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