New analysis reveals that extra weight is linked to an particularly excessive danger of growing breast most cancers in postmenopausal ladies with heart problems. The findings are printed in Most cancers.
Though greater physique mass index (BMI) is a identified danger issue for breast most cancers in postmenopausal ladies, it is unclear whether or not this danger differs amongst ladies with and with out heart problems or sort 2 diabetes. To research, a group led by Heinz Freisling, Ph.D., of the Worldwide Company for Analysis on Most cancers (the specialised most cancers company of the World Well being Group) analyzed information from the European Potential Investigation into Most cancers and Diet (EPIC) and UK Biobank on 168,547 postmenopausal ladies who didn’t have sort 2 diabetes or heart problems once they agreed to take part.
After a median follow-up of 10.7 years in EPIC and 10.9 years within the UK Biobank, 6,793 postmenopausal ladies developed breast most cancers. In a pooled evaluation of each research, every 5 kg/m2 enhance in BMI was related to a 31% greater danger of breast most cancers in ladies who developed heart problems throughout follow-up and a 13% greater danger in ladies with out heart problems. The event of sort 2 diabetes didn’t appear to have an effect on breast most cancers danger: Ladies with or with out sort 2 diabetes had a equally elevated breast most cancers danger associated to greater BMI.
The mixture of obese (BMI ≥ 25 kg/m2) and heart problems was estimated to result in 153 extra instances of breast most cancers per 100,000 individuals per yr than anticipated.
“The findings of this examine may very well be used to tell risk-stratified breast most cancers screening packages,” mentioned Dr. Freisling. “This examine also needs to encourage future analysis to incorporate ladies with a historical past of cardiovascular illnesses in weight-loss trials for breast most cancers prevention.”
Extra data:
Physique mass index and breast most cancers danger amongst postmenopausal ladies with and with out cardiometabolic illnesses: findings from two potential cohort research in Europe, Most cancers (2025). DOI: 10.1002/cncr.35911
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How physique mass index impacts breast most cancers danger in postmenopausal ladies with and with out heart problems (2025, July 7)
retrieved 7 July 2025
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