Mixture of weight problems remedy tirzepatide and menopause hormone remedy fuels weight reduction

Utilizing tirzepatide and menopause hormone remedy on the identical time results in elevated weight reduction in postmenopausal girls with chubby or weight problems in contrast to make use of of tirzepatide therapy alone, in accordance with a research being introduced Saturday at ENDO 2025, the Endocrine Society’s annual assembly in San Francisco, Calif.

“These knowledge are the primary to indicate the mixed use of tirzepatide and menopause hormone remedy considerably will increase therapy effectiveness in postmenopausal girls,” mentioned Regina Castaneda, M.D., analysis fellow for the Division of Endocrinology on the Mayo Clinic in Jacksonville, Fla.

“Earlier research of the remedy semaglutide discovered comparable outcomes. Attaining these outcomes with a second weight problems remedy might point out a broader efficacy development for pairing these two lessons of medicines.”

Menopause-related hormonal modifications typically end in elevated stomach fats, decreased muscle mass and altered power expenditure, which ends up in weight achieve and places hundreds of thousands of ladies in danger for growing coronary heart illness and different severe well being points.

To substantiate the speculation that concurrent menopause hormone remedy enhances the effectiveness of tirzepatide for weight reduction in postmenopausal girls, researchers carried out a real-world research utilizing the digital medical data of 120 postmenopausal girls over a median period of 18 months. The research included two cohorts: 40 girls utilizing menopause hormone remedy concurrently with tirzepatide and 80 girls utilizing tirzepatide alone.

The outcomes confirmed superior complete physique weight reduction proportion for girls utilizing tirzepatide plus menopause hormone remedy (17%) in comparison with these utilizing tirzepatide alone (14%). As well as, a better proportion of menopause hormone remedy customers (45%) additionally achieved not less than 20% complete physique weight reduction, in comparison with 18% of menopause hormone remedy non-users.

“The data garnered by way of this new research supplies vital insights to develop more practical and personalised weight administration interventions to cut back a postmenopausal lady’s danger of chubby and obesity-related well being problems,” mentioned Maria Daniela Hurtado Andrade, M.D., Ph.D., assistant professor of medication and advisor for the Division of Endocrinology on the Mayo Clinic.

“This research underscores the pressing want for additional analysis to raised perceive how weight problems medicines and menopause hormone remedy work collectively. Gaining this data might vastly enhance the well being and well-being of hundreds of thousands of postmenopausal girls. It additionally factors to the necessity for higher methods to make these therapies extra accessible and obtainable to those that want them.”