Trinity researcher’s findings spotlight potential causal hyperlink between MS and Epstein Barr virus, opening up the opportunity of new improved remedies
A neurologist has been honoured for his current work in a number of sclerosis (MS) analysis, together with a big breakthrough in serving to us to grasp and higher deal with the situation.
Dr Hugh Kearney, St James’s Hospital
Dr Hugh Kearney of St James’s Hospital obtained the Analysis Affect Award finally evening’s Trinity Faculty of Medication Analysis Awards 2025.
Dr Kearney obtained the award in recognition of the novel blood take a look at just lately developed by his analysis crew, which permits well being practitioners to estimate the power of the immune response in folks with MS.
The take a look at was developed after sufferers with MS, who have been additionally receiving antiviral medication for HIV, discovered that their MS signs appeared to resolve.
Given earlier hyperlinks between MS and the Epstein-Barr virus (EBV), Dr Kearney’s crew started work on a blood take a look at to quantify the physique’s immune response to the virus, which generally presents as glandular fever.
To check if it labored, they took blood samples from 145 individuals who had both MS, epilepsy or no current medical situation. Although lab exams, every individual was discovered to have had indicators of earlier EBV an infection.
They discovered that the immune response to EBV was larger in folks with MS than it was in folks from both of the 2 different teams. This helps the concept that it’s the immune response to EBV that’s liable for inflicting MS.
Additionally they uncovered that present MS medication have an effect on the immune response to EBV. Medicine that deplete circulating immune cells (generally known as B cells) have been proven in MS sufferers to create an immune response to EBV that was equal to the immune response that wholesome members needed to the virus.
“One of many main goals of our examine has been to develop a possible option to report the impact of medication that concentrate on EBV in MS in scientific trials,” stated Dr Kearney in an article revealed in The Dialog.
“We imagine that testing for virus ranges alone wouldn’t suffice, because the illness is brought on by an immune response. We imagine our new blood take a look at has the potential for use in future scientific trials utilizing antivirals or vaccines towards EBV in MS.”
Now in its fourth 12 months, the Trinity Faculty of Medication Analysis Awards help early profession researchers to develop their profession and construct capability of their respective analysis fields.
The ceremony additionally handed out 4 analysis seed awards, every valued at €10,000, to offer early to mid-career researchers with a possibility to develop their very own analysis concepts as an impartial investigator on a pilot grant.
The 2025 recipients of this award embrace Dr Donal Cox and Dr Grainne Jameson, researchers on the Trinity Translational Medication Institute (TTMI); in addition to Dr Louise Brennan, social prescribing coordinator on the Mercer’s Institute for Profitable Ageing; and Dr Laura Kane, a surgical analysis fellow in Trinity’s Faculty of Medication.
Dr Nickola Pallin, senior post-doctoral analysis fellow in most cancers survivorship, was introduced with the short-term journey award, which goals to permit mid-career researchers develop their analysis endeavours by way of worldwide collaboration and lift their profiles each at residence and overseas.
